See the eye, See the brain

Technologies from Phoenix Research Labs empower
the observation of CNS disorders in translational research.
Access to the disease status is validated
through in vivo observations,
enabling longitudinal studies.

Phoenix Research Labs technology delivers a complete assessment for eye and eye-brain research.

IMAGING:
Micron IV Retinal Microscope

The Micron IV in vivo bright field retinal imaging microscope serves as the host platform to deliver comprehensive assessment. High resolution wide-field imaging is quickly obtained with the capability to obtain arbitrary fluorescent images. The Micron IV captures stunning retinal images in still or movie format.

STRUCTURE:
Image-Guided OCT

Easily add high resolution optical coherence tomographer to the Micron IV and observe the retinal layers in vivid detail. The image-guided capability delivers accurately located measurements in repeated sessions for longitudinal studies.

FUNCTION:
ERG

Add regional (or global) electrophysiology with our Ganzfeld ERG and Image-Guided Focal ERG. The advanced capabilities of the Phoenix ERG systems allows separate assessment of M and S cones and rods. Comprehensive, integrated, and powerful—see the eye, see the brain.

Significant eye-brain research publications

Observation of Parkinson’s proteins in the mouse eye

Using mice genetically engineered to express a fluorescently tagged version of a key protein involved with the pathology of Parkinson’s disease, the developing neuropathology of Parkinson’s was observable using the Micron retinal imaging microscope in the fluorescent imaging mode. The developing pathology was quantitatively studied in vivo over time.

PDFFLAT Click here to download “Validation of retinal imaging for characterizing alpha-synuclein-eGFP deposition in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies”

PDFFLAT Click here to download “Neuropore Therapies Inc. and collaborators at the University of California, San Diego complete a study on the progression of Parkinson’s disease in Laboratory Animals Using Phoenix Research Labs’ Retinal Imaging Technology”

Visualization of ß Amyloid plaques in the mouse eye

Non-invasive detection and monitoring of Alzheimer’s disease was achieved through in vivo retinal imaging using the Micron retinal imaging microscope in fluorescent mode. Curcumin was systemically administered to AD-Tg mice as a safe labeling for fluorochrome b-amyloid plaques present in the retina . The fluorescent imaging mode of the Micron was used to clearly detect and follow the progression of plaques in the eye with detection in the eye preceding detection in the brain.

PDFFLAT Click here to download Alzheimer’s references

Stem cell rescue of vision in rats

The use of pluripotent stem cells in RCS rats was evaluated as a means to improve visual function in RCS rats. A region of the retina was treated and the image guided focal ERG added to the Micron platform was used for testing. The electrical response of both the treated and un-treated portions of the retina of the same eye were tested with a significant increase demonstrated for the treated region.

PDFFLAT Click here to download Stem Cell references